Gnarus Systems

 
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Cat-SAR Models

CURRENT CAT‐SAR® MODELS

Below is a listing and summary of the cat-SAR models currently available or under development. Leave-one-out validation (LOO) results are included as sensitivity, specificity, and observed correct predictions (OCP). The models listed were parameterized to return models with near-equal sensitivity and specificity. Other parameters could be used to develop models with potentially higher OCP values or higher specificity values (useful for risk aversion).

MUTAGENESIS/GENOTOXICITY
Salmonella, NTP
Salmonella, Benchmark*
Micronucleus, Rosenkranz
Micronucleus, NTP

CARCINOGENESIS
Mouse Carcinogenesis
Rat Carcinogenesis
Non-Mutagenic Carcinogenesis

DEVELOPMENTAL TOXICITY
Human Teratogenicity
Mouse Developmental
Rat Developmental
Rabbit Developmental
Human Development

SENSITIZATION AND IRRITATION
Allergic Contact Dermatitis: Marginal as positive
Allergic Contact Dermatitis: Marginal as negative
Mouse Local Lymph Node
Ocular Irritation, Rosenkranz
Respiratory Sensitization, Karol
Corrosion (Severe Skin Burns and Eye Damage)*
Skin Irritation*
Serious Eye Damage*
Serious Eye Irritation*

ENDOCRINE DISRUPTORS/ESTROGEN MIMICS
ESCREEN, MCF-7
FDA NCTR Estrogen Receptor

*Under Development

For a complete list of models and validation results see:
cat-SAR models data v6

 
 
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Consulting Service

Gnarus Systems offers predictive toxicological assessment of chemicals, SAR model development, and virtual screening on an ad hoc basis.

Direct Access

For larger projects, Gnarus Systems can provide users with secure cloud-based access to the cat-SAR expert system along with validated predictive models.

Complete System

Similar to "Direct Access" with the added advantage that users can update/alter exisitng models as well as produce models with user specific data. In this case, users can develop, validate, and use models based on private or proprietary data.